Biologists describe key mechanism in early embryo development

ScienceDaily (Oct. 20, 2011) ? New York University and University of Iowa biologists have identified a key mechanism controlling early embryonic development that is critical in determining how structures such as appendages -- arms and legs in humans -- grow in the right place and at the right time.

In a paper published in the journal PLoS Genetics, John Manak, an assistant professor of biology in the UI College of Liberal Arts and Sciences, and Chris Rushlow, a professor in NYU's Department of Biology, write that much research has focused on the spatial regulatory networks that control early developmental processes. However, they note, less attention has been paid to how such networks can be precisely coordinated over time.

Rushlow and Manak find that a protein called Zelda is responsible for turning on groups of genes essential to development in an exquisitely coordinated fashion.

"Zelda does more than initiate gene networks -- it orchestrates their activities so that the embryo undergoes developmental processes in a robust manner at the proper time and in the correct order," says Rushlow, part of NYU's Center for Developmental Genetics.

"Our results demonstrate the significance of a timing mechanism in coordinating regulatory gene networks during early development, and bring a new perspective to classical concepts of how spatial regulation can be achieved," says Manak, who is also assistant professor of pediatrics in the Roy J. and Lucille A. Carver College of Medicine and researcher in the UI Roy J. Carver Center for Genomics.

The researchers note that their findings break new ground.

"We discovered a key transcriptional regulator, Zelda, which is the long-sought-after factor that activates the early zygotic genome," says Rushlow.

"Initially, the embryo relies on maternally deposited gene products to begin developing, and the transition to dependence on its own zygotic genome is called the maternal-to-zygotic transition," she adds. "Two hallmark events that occur during this transition are zygotic gene transcription and maternal RNA degradation, and interestingly, Zelda appears to be involved in both processes."

The research showed that when Zelda was absent, activation of genes was delayed, thus interfering with the proper order of gene interactions and ultimately disrupting gene expression patterns, the researchers noted, adding that the consequence to the embryo of altered expression patterns is a drastic change in the body plan such that many tissues and organs are not formed properly, if at all.

The researchers used Drosophila, or fruit flies, to investigate these regulatory networks. The fruit fly has the advantage of being a tractable genetic model system with a rapid developmental time, and many of the genetic processes identified in flies are conserved in humans. Additionally, pioneering fly research has led to many of the key discoveries of the molecular mechanisms underlying developmental processes in complex animals.

The study brought together Rushlow, who discovered Zelda and is an expert in genetic regulatory networks in development, and Manak, a genomics expert whose laboratory focuses on how a genome is constructed and coordinately functions.

"I had always wanted to work with Chris, and this was a wonderful opportunity for us to combine our complementary areas of expertise in a truly synergistic fashion," says Manak.

"Our collaboration is a marvelous example of how a problem can be viewed from two different perspectives, a systems view of early gene networks and an individualistic view of single genes and single embryos, and result in novel and significant discoveries," says Rushlow.

The project's other researchers were: Stephen Butcher of the UI Departments of Pediatrics and Biology; and Chung-yi Nien, Hsiao-lan Liang, Yujia Sun, Shengbo Fu, Tenzin Gocha, and Nikolai Kirov, all of the Center for Developmental Genetics, part of NYU's Department of Biology.

The research was funded by grants from the National Institutes of Health.

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Journal Reference:

  1. Chung-Yi Nien, Hsiao-Lan Liang, Stephen Butcher, Yujia Sun, Shengbo Fu, Tenzin Gocha, Nikolai Kirov, J. Robert Manak, Christine Rushlow. Temporal Coordination of Gene Networks by Zelda in the Early Drosophila Embryo. PLoS Genetics, 2011; 7 (10): e1002339 DOI: 10.1371/journal.pgen.1002339

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/XHcN2aYTRh4/111020191852.htm

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Seeger, Guthrie join Wall Street protest

Activist musician Pete Seeger, 92, center, sings before a crowd of nearly a thousand demonstrators sympathetic to the Occupy Wall Street protests at a brief acoustic concert in Columbus Circle, Saturday, Oct. 22, 2011, in New York. The demonstrators marched down Broadway singing "This Little Light of Mine" and other folk and gospel songs while ad-libbing lines about corporate greed and social justice. (AP Photo/John Minchillo)

Activist musician Pete Seeger, 92, center, sings before a crowd of nearly a thousand demonstrators sympathetic to the Occupy Wall Street protests at a brief acoustic concert in Columbus Circle, Saturday, Oct. 22, 2011, in New York. The demonstrators marched down Broadway singing "This Little Light of Mine" and other folk and gospel songs while ad-libbing lines about corporate greed and social justice. (AP Photo/John Minchillo)

Activist musician Pete Seeger, 92, center, marches with nearly a thousand demonstrators sympathetic to the Occupy Wall Street protests for a brief acoustic concert in Columbus Circle, Friday, Oct. 21, 2011, in New York. The demonstrators marched down Broadway singing "This Little Light of Mine" and other folk and gospel songs while ad-libbing lines about corporate greed and social justice. (AP Photo/John Minchillo)

Activist musician Pete Seeger, 92, exits the Symphony Space on the Upper West Side to march with nearly a thousand demonstrators sympathetic to the Occupy Wall Street protests for a brief acoustic concert in Columbus Circle, Friday, Oct. 21, 2011, in New York. The demonstrators marched down Broadway singing "This Little Light of Mine" and other folk and gospel songs while ad-libbing lines about corporate greed and social justice. (AP Photo/John Minchillo)

Demonstrators symphathetic to the Occupy Wall Street protests wait for activist musician Pete Seeger, 92, to exit the Symphony Space on the Upper West Side and march together to Columbus Circle for a brief acoustic concert, Friday, Oct. 21, 2011, in New York. Nearly a thousand people marched down Broadway singing "This Little Light of Mine" and other folk and gospel songs while ad-libbing lines about corporate greed and social justice. (AP Photo/John Minchillo)

Demonstrators sympathetic to the Occupy Wall Street protests sing at a brief acoustic concert featuring activist musician Pete Seeger, not shown, in Columbus Circle, Saturday, Oct. 22, 2011, in New York. The demonstrators marched down Broadway singing "This Little Light of Mine" and other folk and gospel songs while ad-libbing lines about corporate greed and social justice. (AP Photo/John Minchillo)

(AP) ? Folk music legend Pete Seeger and '60s folk singer Arlo Guthrie joined Occupy Wall Street demonstrators Friday in their campaign against corporate greed while residents near the protest park encampment pushed to regain some peace and quiet in their neighborhood.

Seeger joined in the Occupy Wall Street protest Friday night, replacing his banjo with two canes as he marched with throngs of people in New York City's tony Upper West Side past banks and shiny department stores.

The 92-year-old Seeger, accompanied by musician-grandson Tao Rodriguez Seeger, composer David Amram, and bluesman Guy Davis, shouted out the verses of protest anthems as the crowd of about 1,000 people sang and chanted.

They marched peacefully over more than 30 blocks from Symphony Space, where the Seegers and other musicians performed, to Columbus Circle. Police watched from the sidelines.

Occupy Wall Street began a month ago in lower Manhattan among a few young people, and has grown to tens of thousands around the country and the world. A recent Associated Press-GfK poll says more than one-third of the country supports the Wall Street protesters, and even more ? 58 percent ? say they are furious about America's politics.

But the encampment at Zuccotti Park has become more than a tolerable nuisance, some neighborhood residents say. At a meeting Thursday, they complained of protesters urinating in the streets and beating drums in the middle of the night. Some called for the protesters to vacate the park.

The area's community board voted unanimously for a resolution that recognized the protesters' First Amendment rights while calling for a crackdown on noise and public urination and defecation.

U.S. Rep. Jerrold Nadler, Manhattan Borough President Scott Stringer and state Sen. Daniel Squadron said in a statement that the resolution was "an attempt to establish a sensible framework that respects the protesters' fundamental rights while addressing the very real quality of life concerns for residents and businesses around Zuccotti Park."

Asked about Occupy Wall Street on WOR Radio on Friday, Mayor Michael Bloomberg said the protesters' leaderless structure has made it difficult to negotiate with them.

Occupy Wall Street spokesman Han Shan, who has served as a liaison between protesters and local elected officials, agreed the protesters needed to be better neighbors. Shan, who attended the meeting, promised to limit the noise.

At Columbus Circle, Seeger and friends walked to the chant of "We are the 99 percent" and "We are unstoppable; another world is possible." Seeger stopped to bang a metal statue of an elephant with his cane ? to cheers from the crowd.

At the center of the plaza, Seeger and Amram were joined by Guthrie in a round of "We Shall Overcome," a protest anthem made popular by Seeger.

After more singing, Seeger asked for a mic check to tell the crowd: "The words are simple: I could be happy spending my days on the river that flows both way-ay-ays."

During the march, the younger Seeger, in troubadour fashion like his grandfather, walked among the protesters playing songs. Amra took up a flute and others enlivened the night protest with the sounds of the accordion, banjos, and guitars.

At the front of the throng, marchers held American flags and a large blue flag that said: "Revolution Generation ... Debt is Slavery." Along the way, the crowd sang protest songs made popular or written by Seeger, Woody Guthrie, and others of the protest era.

___(equals)

Associated Press writer Karen Matthews contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-10-22-Wall%20Street%20Protest/id-9b74068a868049739e992d0db268f3b8

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Ben Cherington Next Red Sox GM? Boston Likely To Promote Theo Epstein Aide

BOSTON -- Ben Cherington will have plenty to do if, as expected, he follows Theo Epstein as the general manager of the Boston Red Sox.

He'll also have plenty to work with.

Cherington is expected to be promoted on Tuesday, when the Red Sox have scheduled a news conference to introduce Epstein's replacement. Epstein resigned from Boston to take over as president of baseball operations for the Chicago Cubs on Friday, and the teams said they would hold off on more announcements out of respect for the teams in the World Series; Tuesday is the next off-day.

Cherington's first job will be to find a manager to replace Terry Francona, a two-time World Series winner who admitted he lost the clubhouse in his eighth season and was let go after the team's unprecedented September collapse. The coaching staff also will need to be rebuilt as pitching coach Curt Young left for the Oakland Athletics earlier Friday.

Cherington also will have to deal with the fallout from the team's 7-20 September that left it one game short of the playoffs. The pitching staff disintegrated over the final month, followed by news reports that several starters were drinking beer and eating fast-food fried chicken in the clubhouse during games.

Among them was John Lackey, who was 12-12 with a 6.41 ERA in the second year of a five-year, $82.5 million deal. The Red Sox are unlikely to find a taker unless they eat most of Lackey's remaining salary. Cherington also will be saddled with six more years of Carl Crawford's contract, a seven-year, $142 million deal signed by Epstein.

But the Red Sox have reason to be hopeful with the core of the team that went 81-43 over a 4 1/2-month stretch of the season and a payroll that is among the biggest in baseball. All-Star Adrian Gonzalez just finished the first year of a seven-year, $154 million deal, Jacoby Ellsbury developed into an MVP candidate, and Dustin Pedroia and Kevin Youkilis are locked up long term.

Josh Beckett was an ace for most of the year and Jon Lester remains one of the top lefties in the AL, but their performance in September was a key reason for the collapse. Clay Buchholz is expected to return from a stress fracture.

J.D. Drew's contract is up, giving the Red Sox some payroll flexibility, and Daisuke Matsuzaka is at the end of the six-year deal that brought him over from Japan for a total of $103 million.

They'll need the money to re-sign closer Jonathan Papelbon, who can file for free agency for the first time, and for designated hitter David Ortiz, who's also a free agent.

Because Epstein's move was in the works for a while, Cherington has been filling in as GM since the regular season ended.

Cherington also served as co-GM during the three-month period after the 2005 season when Epstein walked away from the Red Sox. He shared the job with Jed Hoyer. Now the San Diego Padres' GM, Hoyer is expected to be Epstein's top hire with the Cubs.

Because the teams were unable to agree to compensation for allowing Epstein out of the last year of his contract, Hoyer and Cherington will probably have to work on that, too.

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Source: http://www.huffingtonpost.com/2011/10/21/ben-cherington-red-sox-gm-theo-epstein_n_1026129.html

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Crime novelist Elmore Leonard, wife divorcing

In this Sept. 28, 2010 photo, author Elmore Leonard is interviewed at his home in Bloomfield Township, Mich. Court records show Leonard is divorcing his wife of 18 years. The Detroit News reports Thursday, Oct. 20, 2011 that he and Christine Leonard split earlier this year and she filed for divorce in May. Oakland County Circuit Court records say Christine cited a breakdown in the marriage for unspecified reasons. (AP Photo/Carlos Osorio, FILE)

In this Sept. 28, 2010 photo, author Elmore Leonard is interviewed at his home in Bloomfield Township, Mich. Court records show Leonard is divorcing his wife of 18 years. The Detroit News reports Thursday, Oct. 20, 2011 that he and Christine Leonard split earlier this year and she filed for divorce in May. Oakland County Circuit Court records say Christine cited a breakdown in the marriage for unspecified reasons. (AP Photo/Carlos Osorio, FILE)

(AP) ? Court records show acclaimed crime novelist Elmore Leonard is divorcing his wife of 18 years.

The Detroit News reports (http://j.mp/q3iWLm ) Thursday that he and Christine Leonard split earlier this year and she filed for divorce in May. Oakland County Circuit Court records say Christine Leonard cited a breakdown in the marriage for unspecified reasons.

Elmore Leonard's attorney Gerald Cavellier calls it "pretty standard as divorces go." Christine Leonard's attorney Joseph Aviv says Judge Edward Sosnick disqualified himself from the case because he presided over the couple's wedding.

A trial is set for Dec. 12.

The 86-year-old Leonard, who lives in suburban Detroit, has written more than 40 Westerns, crime novels and mysteries. Many of his books ? notably "Out of Sight," ''Get Shorty" and "Be Cool" ? have become films.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-10-21-US-People-Elmore-Leonard/id-4848532d7d5c4e618b940d0d4a620339

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Thailand flooding could affect PC supplies, prices

FILE - In this Oct. 17, 2011, file photo, factory workers join hands in stacking sand bags to make floods barriers at Nawa Nakhon industrial estate on the outskirts of Bangkok, Thailand. The deadly flooding in Thailand, a slow-motion disaster that's been rolling through the country since August, has hurt one of the region's biggest industries: computer hard drives. (AP Photo/Apichart Weerawong, File)

FILE - In this Oct. 17, 2011, file photo, factory workers join hands in stacking sand bags to make floods barriers at Nawa Nakhon industrial estate on the outskirts of Bangkok, Thailand. The deadly flooding in Thailand, a slow-motion disaster that's been rolling through the country since August, has hurt one of the region's biggest industries: computer hard drives. (AP Photo/Apichart Weerawong, File)

(AP) ? The personal computer industry, already reeling from depressed demand, has been dealt another setback: Massive flooding in Thailand has curtailed production of a critical component ? computer storage drives.

Factories producing a third of the country's hard drives have temporarily closed as flooding has gradually spread since August. Prices have spiked, and Apple warned that its Mac products will likely be affected.

Computer manufacturers, the companies that supply hard drives and the makers of components for those drives are all bracing for troubles. What's not yet clear is what extent PC production lines will be affected and whether PC makers will absorb costs or pass them along to consumers.

Thailand makes about a quarter of the world's hard drives and is the second-largest producer behind China, according to IHS iSuppli. Market research firm IDC estimates that the flooding has already affected a third of the country's output, equating to more than 120 million hard drives a year. Avian Securities says the slowdown is already leading to price spikes that have added several dollars to the cost of some drives.

The flooding has killed 317 people, mostly from drowning. Nearly 9 million people have been displaced or otherwise affected. Estimates of the economic cost were $3 billion and rising.

The setback is particularly acute for the computer industry because it follows other troubles. Demand has slowed, particularly in the U.S. and Europe, because of debt and unemployment fears and the growing popularity of tablet computers, which causes many consumers to delay replacing PCs. In addition, the March 11 earthquake and tsunami in Japan hurt supplies of memory chips.

The biggest hard drive makers ? Seagate Technology PLC and Western Digital Corp. ? have warned of delays.

Western Digital has suspended its operations in Thailand. Floodwaters have affected two factories, which shut down last week. The company said its other hard drive manufacturing facilities, located in Malaysia, are fully operational. But it said flooding will have a significant impact on its ability to meet demand through the end of the year. Western Digital's Thailand operations account for more than half of the company's total hard drive output. Western Digital's stock has fallen 15 percent since the company announced its delays last week.

Seagate says that its factories in Thailand are operational but warned that it is having difficulty getting some components. It said supply will be constrained the rest of the year, though the magnitude of the disruption is currently unclear.

Toshiba has also suspended its Thailand hard disk operations, as have a number of hard disk component suppliers.

Big computer makers are worried.

On Tuesday, Apple Inc. CEO Tim Cook said he is "virtually certain there will be an overall industry shortage of disk drives." But because a thorough assessment of the damage hasn't been possible, he said he couldn't immediately give a timeline for recovery. Cook warned that Apple's Mac lines would be most affected. Most of its mobile devices, including the iPhone and the iPad, use a different type of storage called flash memory.

Dell Inc., the No. 3 PC maker, said it expects minimal impact to supply through the current quarter, which ends this month. The company said it is working with suppliers to assess the impact for the rest of the year. Hewlett-Packard Co., the leading computer maker, said it is monitoring the situation in Thailand as operations there remain open.

Gartner Inc. analyst John Monroe called the disruptions "very serious and ongoing" and said they affect production of roughly half of the "spindle" motors that turn the hard disks, along with other technologies. Monroe expects slowdowns through March.

"We do not know yet what we do not know, many unknown unknowns," Monroe said.

But as was the case with the crisis in Japan, the industry has some manufacturing safeguards for natural disasters. Production is generally spread among several countries. Some analysts were optimistic that the delays would be short-lived.

John Rydning, an analyst with IDC, said that the hard drive industry's supply chain is "highly redundant and remarkably resilient." He noted that the hard drive industry recovered quickly from the Japanese disaster without any major disruption.

"It is premature to say the flooding will lead to potentially billions of dollars in lost revenue," he said in an email. "Not an impossible scenario, but we need to hear more about the clean-up efforts underway before making that call."

Stacy Smith, chief financial officer for Intel Corp., the biggest maker of computer microprocessors, told analysts Tuesday that he doesn't believe there will be an impact on PC sales in the current quarter.

"A combination of alternate supplies and inventory levels will carry us through," he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2011-10-19-Computer%20Supply%20Shortages/id-90d4e21634144db09b50a5f2b50d1707

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UNC's Rubinow elected to Institute of Medicine

[ Back to EurekAlert! ] Public release date: 19-Oct-2011
[ | E-mail | Share Share ]

Contact: Tom Hughes
tahughes@unch.unc.edu
919-966-6047
University of North Carolina School of Medicine

David R. Rubinow, MD, Assad Meymandi Distinguished Professor and chair of psychiatry, is among the 65 new members announced by the institute on Oct. 17

CHAPEL HILL, N.C. A professor in the University of North Carolina at Chapel Hill School of Medicine has been elected to the Institute of Medicine, considered one of the nation's highest honors for those in the fields of health and medicine.

David R. Rubinow, MD, Assad Meymandi Distinguished Professor and Chair of Psychiatry, is among the 65 new members announced by the institute on Monday (Oct. 17).

Rubinow is an internationally recognized expert in the evaluation and treatment of women with mood disorders that occur during periods of hormonal change. He is also the founder of the UNC Center for Women's Mood Disorders, which recently opened an inpatient unit for women with moderate to severe postpartum depression (PPD). The 5-bed Perinatal Psychiatry Inpatient Unit is the first of its kind in the United States.

He came to UNC after a long and distinguished 26-year career at the National Institute of Mental Health in Bethesda, Md. There he started as a staff psychiatrist in 1979 and advanced through a series of positions of increasing responsibility, culminating with his becoming the Clinical Director of NIMH in 1987 and the founding chief of the NIMH's Behavioral Endocrinology Branch in 1996. He held both positions until 2005, when he accepted his current appointment at UNC.

Rubinow has received numerous awards for his research, his clinical supervision and training and his scientific administration. He has also authored or co-authored more than 350 scientific publications.

###

The institute, part of the National Academy of Sciences, has 1,870 members, including 19 from UNC with the addition of Rubinow. Current members elect new members from among candidates nominated for their accomplishments and contributions to the advancement of the medical sciences, health care and public health. Members commit to volunteer on institute committees, which carry out a broad range of studies on health policy issues.

For more information about the institute, go to http://www.iom.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


[ Back to EurekAlert! ] Public release date: 19-Oct-2011
[ | E-mail | Share Share ]

Contact: Tom Hughes
tahughes@unch.unc.edu
919-966-6047
University of North Carolina School of Medicine

David R. Rubinow, MD, Assad Meymandi Distinguished Professor and chair of psychiatry, is among the 65 new members announced by the institute on Oct. 17

CHAPEL HILL, N.C. A professor in the University of North Carolina at Chapel Hill School of Medicine has been elected to the Institute of Medicine, considered one of the nation's highest honors for those in the fields of health and medicine.

David R. Rubinow, MD, Assad Meymandi Distinguished Professor and Chair of Psychiatry, is among the 65 new members announced by the institute on Monday (Oct. 17).

Rubinow is an internationally recognized expert in the evaluation and treatment of women with mood disorders that occur during periods of hormonal change. He is also the founder of the UNC Center for Women's Mood Disorders, which recently opened an inpatient unit for women with moderate to severe postpartum depression (PPD). The 5-bed Perinatal Psychiatry Inpatient Unit is the first of its kind in the United States.

He came to UNC after a long and distinguished 26-year career at the National Institute of Mental Health in Bethesda, Md. There he started as a staff psychiatrist in 1979 and advanced through a series of positions of increasing responsibility, culminating with his becoming the Clinical Director of NIMH in 1987 and the founding chief of the NIMH's Behavioral Endocrinology Branch in 1996. He held both positions until 2005, when he accepted his current appointment at UNC.

Rubinow has received numerous awards for his research, his clinical supervision and training and his scientific administration. He has also authored or co-authored more than 350 scientific publications.

###

The institute, part of the National Academy of Sciences, has 1,870 members, including 19 from UNC with the addition of Rubinow. Current members elect new members from among candidates nominated for their accomplishments and contributions to the advancement of the medical sciences, health care and public health. Members commit to volunteer on institute committees, which carry out a broad range of studies on health policy issues.

For more information about the institute, go to http://www.iom.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-10/uonc-ure101911.php

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Soulja Boy?s Arrest Could Help Movie Release

Rapper Soulja Boy found himself riding in the back of a police car this week after the car he was riding in was pulled over. Unfortunately for him, what could have been a minor ticket turned into a major problem. He first became famous for an original song that included a new dance. The track and the dance swept the hip-hop world, even though it was ridiculously simple. After that he kind of disappeared. Until now. All of a sudden he is in the news again, but this time it?s not for his music. The 21-year-old was riding (or driving) in a car that had a missing taillight. Police in Carroll County Georgia pulled over the vehicle for a routine stop, but said they smelled marijuana. After that they decided to search the car, which turned up a gun and a large amount of pot and cash. Soulja Boy is being charged with possession with intent to distribute, and even a weapons charge. It sounds a lot like what happened to Lil Wayne. The strangest part about this is that he was just about to release a DVD called ?Soulja Boy: The Movie.? That sounds really stupid and boring, and [...]

Source: http://feedproxy.google.com/~r/RightCelebrity/~3/pDHvYRdBQQQ/

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iPhone 4S lacks "Enable 3G" switch

If you're among the teeming masses holding a brand new iPhone 4S in your hands, you may be surprised (as we were) to find there's something conspicuously absent from the Network Settings menu on your new device: specifically the ability to manually shut off 3G data. After receiving word, and a screenshot, from a helpful tipster, rocking a 4S on Vodafone's network, we found the same option missing from our own AT&T iteration. Of course this isn't the sort of thing that's likely to have an impact on most users, but if you're the type that likes to squeeze every last bit of juice out of that Apple, the omission could cause some frustration. We gave Apple support a call to see what they had to say, and were told AppleCare has no official response on the matter. If you're lamenting the loss of the 3G flip-switch sound off in the comments below.

[Thanks, Chris and Charlie]

iPhone 4S lacks "Enable 3G" switch originally appeared on Engadget on Sat, 15 Oct 2011 14:54:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/yJDo65NbJP8/

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Euroleague to the fore amid NBA lockout (Reuters)

BELGRADE (Reuters) ? The cancellation of the first two weeks of games in the National Basketball League (NBA) has left Europe's Euroleague, albeit temporarily, as the world's top club competition promising an exciting season.

League owners and players in the NBA have been unable to resolve a labor dispute, meaning that the season will not start before November 14 and more games are under threat with a collective bargaining agreement still looking distant.

Europe's premier club competition, which starts on Monday with a curtain-raiser between six-times winners CSKA Moscow and Lithuanian team Zhalgiris Kaunas, has benefited as a result with some top contenders bolstering their ranks.

But Jordi Bertomeu, the Euroleague's Chief Executive Officer (CEO), warned the exodus of NBA players to Europe was only temporary as most of them have pledged to return when the lockout across the Atlatnic ends.

"Teams that have decided to sign players knowing they are likely to leave understand the risks, both good and bad," Bertomeu told the Euroleague's official website (www.eurolague.net).

"The good one is that such a player will help win games while he's here, the bad one is that team chemistry will be difficult to maintain when a player leaves.

"But fans new and old can expect to see great basketball, first and foremost.

"The way our competition is structured, with almost no games that do not impact the standings in some way, the teams are playing for survival from the opening night."

The top four teams from each of the four preliminary pools of six will advance to the second stage, featuring four groups of four, where the top two teams from each group will qualify for the business end of the competition.

The knockout stage begins with best-of-five quarter-final series from which the winners advance to the Final Four, with this season's showpiece tournament set for Istanbul next May.

CLEAR VISION

Anadolu Efes Istanbul, who were already boasting a stack of top European performers, have welcomed former Los Angeles Lakers guard Sasha Vujacic, who joined the Turkish contenders from the New Jersey Nets.

The Slovenian, part of the Lakers roster that won the NBA titles in 2009 and 2010, was delighted to have arrived at one of the favorites to reach this season's Euroleague Final Four in their own Sinan Erdem Arena.

"I am very excited to be with a team with a great history, with a clear vision where they want to be in the Eurolegue and what they want to accomplish," Vujacic said.

"It's going to take a lot of hard work to adjust to the European game and adapt to it, but seven years in the NBA, six and a half of them with the Lakers, helped me mature as a player and a person.

"Like the NBA, it's a long season in the Euroleague; it's a marathon and not a sprint so what matters is not how you start but how you finish," said Vujacic, who signed a one-year deal with Efes with an option to extend his contract.

Efes start their campaign with Thursday's tricky tie at Serbian champions Partizan Belgrade, whose Pinoir Arena resembles a cauldron and is one of the most intimidating away courts for any opponents.

Defending champions Panathinaikos Athens, whose squad has remained virtually intact, are at home to Spaniards Unicaja Malaga while last season's finalists Maccabi Tel Aviv are away to Emporio Armani Milan.

Real Madrid, who have signed Dallas Mavericks forward Rudy Fernandez until the NBA lockout ends, visit Belgian champions Belgacom Spirou while bitter Spanish rivals Barcelona travel to Slovenians Olimpija Ljubljana.

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/nm/20111017/sp_nm/us_basketball_euroleague_preview

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